Official Journal of The Academy of Osseointegration
Platelet-Rich Plasma Combined with Decalcified Freeze-Dried Bone Allograft for the Treatment of Noncontained Human Intrabony Periodontal Defects: A Randomized Controlled Split-Mouth Study
Ashish Agarwal, MDS/Narindra Dev Gupta, MDS
PMID: 25171042
DOI: 10.11607/prd.1766
The aim of the present randomized split-mouth clinical trial was to compare plateletrich plasma (PRP) combined with a demineralized freeze-dried bone allograft (DFDBA) to DFDBA with a saline solution in the treatment of noncontained human periodontal intrabony defects. Forty-eight noncontained interproximal intrabony defects in 24 healthy nonsmoking patients diagnosed with chronic periodontitis were randomly assigned to the test group (PRP/DFDBA) or the control group (DFDBA/saline). Clinical (probing pocket depth, clinical attachment level [CAL], and gingival recession [REC]) and radiographic (bone fill, defect resolution, and alveolar crest resorption) measurements were made at baseline and at a 12-month evaluation. Compared with baseline, 12-month results indicated that both treatment modalities resulted in significant changes in all clinical and radiographic parameters. However, the test group exhibited statistically significantly greater changes compared with the control group in CAL (3.15 ± 0.50 versus 2.40 ± 0.61 mm), REC (0.54 ± 0.59 versus 1.23 ± 0.47 mm), bone fill (3.02 ± 0.50 versus 2.37 ± 0.47 mm), and defect resolution (3.29 ± 0.53 versus 2.69 ± 0.38 mm). Findings indicate that a combination of PRP and DFDBA is more effective than DFDBA with saline for the treatment of noncontained intrabony defects. (Int J Periodontics Restorative Dent 2014;34:705–711. doi: 10.11607/prd.1766)
© 2020 Quintessence Publishing Co, Inc |
PRD Home Current Issue Ahead of Print Archive Author Guidelines About |
Submission Form Submit Reprints Permission Advertising |
Quintessence Home Terms of Use Privacy Policy About Us Contact Us Help |